Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum
نویسندگان
چکیده
منابع مشابه
Autoimmunity in Primary Antibody Deficiencies.
Primary antibody deficiencies (PADs) are the most common inherited primary immunodeficiencies in humans, characterized by hypogammaglobulinemia, an inability to produce specific antibodies, and recurrent infections mainly caused by encapsulated bacteria. However, it has been shown that inflammatory disorders, granulomatous lesions, lymphoproliferative diseases, cancer, and autoimmunity are asso...
متن کاملPrimary antibody deficiencies: recognition, clinical diagnosis and referral of patients.
The primary antibody deficiency syndromes are a rare group of immunodeficiencies where diagnostic delay remains common due to limited awareness of the existence and heterogeneity of their presenting features. Referral for specialist assessment leads to earlier diagnosis and appropriate therapy to prevent or limit structural organ and tissue damage. Greater education of healthcare professionals ...
متن کاملPrimary Antibody Deficiencies at Queen Rania Children Hospital in Jordan: Single Center Experience
Background: Primary antibody deficiency, the most common primary immunodeficiency disorder, represents a heterogeneous spectrum of conditions caused by a defect in any critical stage of B cell development and is characterized by impaired production of normal amounts of antigen-specific antibodies. Objective: This retrospective study aimed at description and analysis of demographic, clinical, im...
متن کاملRecognition, Clinical Diagnosis and Management of Patients With Primary Antibody Deficiencies: A Systematic Review
METHODS. Computer literature searches were conducted for randomized clinical trials in medical literature databases including the US National Library of Medicine (Medline), the Excerpta Medica database (EMBASE), the Cochrane Library, the Database of Abstracts of Reviews of Effects (DARE) of the Centre for Reviews and Dissemination (University of York), and the Cumulative Index to Nursing and Al...
متن کاملRecognition, clinical diagnosis and management of patients with primary antibody deficiencies: a systematic review.
The primary purpose of this systematic review was to produce an evidence-based review of the literature as a means of informing current clinical practice in the recognition, diagnosis and management of patients with suspected primary antibody deficiency. Randomized controlled trials (RCTs) were identified from a search of MEDLINE, EMBASE, The Cochrane Library, DARE (CRD website) and CINAHL by c...
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ژورنال
عنوان ژورنال: Journal of Clinical Immunology
سال: 2020
ISSN: 0271-9142,1573-2592
DOI: 10.1007/s10875-020-00773-y